What Role Does the Androgen Receptor Play in Prostate Cancer?
In prostate cancer, AR signaling is a critical driver of cancer cell growth. The disease is initially androgen-dependent, meaning that it relies on androgens to grow. Treatments for prostate cancer often involve androgen deprivation therapy (ADT), which reduces androgen levels or blocks AR activity. This approach is effective initially but can lead to a more aggressive form known as castration-resistant prostate cancer (CRPC), where cancer cells adapt to grow despite low androgen levels.
