What Role Does the Microenvironment Play in Tumor Growth?
The tumor microenvironment, which includes surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix, plays a crucial role in cancer progression. It can either inhibit or promote tumor growth. For instance, immune cells like T-cells and natural killer cells can attack cancer cells, but tumors often create an immunosuppressive environment that protects them from immune attacks. Additionally, cancer-associated fibroblasts can secrete growth factors and cytokines that promote tumor growth and survival.
