What Types of CRISPR Screens are Used in Cancer Research?
There are two main types of CRISPR screens used in cancer research:
Loss-of-function screens: These screens involve knocking out genes to identify those that are essential for cancer cell survival and growth. Genes that, when disrupted, lead to cell death or reduced proliferation are considered potential therapeutic targets. Gain-of-function screens: These screens focus on activating or overexpressing genes to identify those that drive cancer progression. By understanding which genes promote malignancy, researchers can develop strategies to counteract their effects.
