Which Cancers Are Associated with Aberrant Hedgehog Signaling?
Various cancers have been linked to the dysregulation of the Hedgehog pathway. These include basal cell carcinoma (BCC), medulloblastoma, pancreatic cancer, and prostate cancer, among others. In basal cell carcinoma, mutations in the pathway components such as PTCH1 or SMO lead to constitutive activation of the pathway.
