Which Genes are Commonly Affected by Gain of Function Mutations?
Several genes are frequently implicated in cancer through gain of function mutations. Some key examples include: - EGFR (Epidermal Growth Factor Receptor): Mutations in this receptor can lead to excessive cell growth and division. - PIK3CA: Mutations in this gene can activate the PI3K/AKT pathway, promoting cell survival and growth. - BRAF: Mutations in BRAF, particularly the V600E mutation, are common in melanoma and other cancers.
