Why Are KSP Inhibitors Significant in Cancer Treatment?
Traditional chemotherapeutic agents, like vinca alkaloids and taxanes, also target microtubules but lack specificity, affecting both dividing and non-dividing cells. This non-specificity often leads to significant side effects. KSP inhibitors, on the other hand, specifically target the mitotic spindle, offering a more targeted approach to cancer treatment. This specificity can potentially lead to fewer side effects and improved patient outcomes.
