Why Did Finasteride Reduce Low-Grade but Increase High-Grade Prostate Cancer?
The paradoxical increase in high-grade prostate cancer diagnoses led to considerable debate. One theory suggests that finasteride shrinks the prostate, making it easier to detect cancerous lesions, including high-grade ones. Another hypothesis is that finasteride may selectively inhibit low-grade tumors while having less impact on more aggressive forms of cancer.