The long latency periods occur due to several factors: 1. Cellular Changes: Cancer typically develops through a multi-step process involving genetic and epigenetic changes. These changes can take a long time to accumulate to a level that causes malignant transformation. 2. Immune System Interactions: The immune system may initially recognize and destroy abnormal cells, delaying cancer development. 3. Environmental and Lifestyle Factors: Continued exposure to risk factors like tobacco, asbestos, and certain chemicals can contribute to prolonged latency periods. 4. Biological Factors: The age of the individual, hormonal influences, and pre-existing health conditions can also affect the latency period.
