Why Does Prostate Cancer Become Hormone Refractory?
Prostate cancer can become hormone refractory due to several mechanisms. One common cause is the cancer cells' ability to adapt and survive in a low-androgen environment. They may increase the number of androgen receptors or mutate in ways that allow them to use the body's own androgens more effectively. Some cancer cells might produce their own androgens, bypassing the need for external sources entirely.
