Rare tumors pose unique challenges. Due to their rarity, there is often a lack of standardized treatment protocols, making it difficult for clinicians to make informed decisions. Additionally, rare tumors can be biologically diverse, leading to varied responses to treatment. This complexity necessitates a tailored approach to research and care. The Rare Tumor Initiative seeks to harness the power of modern technologies, such as next-generation sequencing and personalized medicine, to better understand and treat these diverse cancer types.