1. Tumor Size Reduction: Shrinking the tumor can make it easier for surgeons to remove it completely. 2. Evaluating Treatment Response: It allows oncologists to see how the cancer responds to treatment, which can inform postoperative therapy. 3. Increased Surgical Options: Smaller tumors may enable less invasive surgical techniques, preserving more of the patient's normal tissue. 4. Eliminating Micrometastases: Preoperative therapy can target and kill microscopic cancer cells that might have spread elsewhere in the body.