Metastasis, the spread of cancer cells to distant organs, is a major cause of cancer-related deaths. For metastasis to occur, cancer cells must detach from the primary tumor, enter the bloodstream, and establish new tumors in other tissues. The blood supply plays a pivotal role in this process by providing a means for cancer cells to disseminate. Additionally, a well-developed blood supply in metastatic sites is essential for the survival and growth of secondary tumors.
