Changes in Skin - Cancer Science

What are the Common Skin Changes Associated with Cancer?

Cancer can manifest in numerous ways, and changes in the skin are often among the first visible signs. These changes can include new growths, sores that don’t heal, or alterations in existing moles. Skin changes can be indicative of various forms of cancer, including skin cancer itself, such as basal cell carcinoma, squamous cell carcinoma, and melanoma.

How to Identify Suspicious Moles and Lesions?

Suspicious moles and lesions are often identified using the ABCDE rule:
- Asymmetry: One half of the mole doesn't match the other.
- Border: Edges are irregular, ragged, or blurred.
- Color: The color is not uniform and may include different shades of brown or black, sometimes with patches of pink, red, white, or blue.
- Diameter: The spot is larger than 6mm across, although melanomas can sometimes be smaller.
- Evolving: The mole is changing in size, shape, or color.

What is Actinic Keratosis?

Actinic keratosis is a precancerous condition characterized by rough, scaly patches on the skin, often resulting from prolonged exposure to the sun. These patches can sometimes develop into squamous cell carcinoma if not treated. It is vital to monitor any rough patches for changes and consult a healthcare provider for appropriate treatment.

Which Skin Cancers are Most Common?

The three most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Basal cell carcinoma is the most frequent and least dangerous, characterized by pearly or waxy bumps. Squamous cell carcinoma can appear as red, scaly patches or sores that may crust or bleed. Melanoma is the most dangerous form, known for its potential to spread to other parts of the body if not detected early.

What are Paraneoplastic Syndromes?

Paraneoplastic syndromes are a group of rare disorders triggered by an abnormal immune response to a cancerous tumor. These syndromes can lead to various skin changes, such as acanthosis nigricans (dark, velvety patches in body folds and creases), dermatomyositis (a rare inflammatory disease causing muscle weakness and skin rash), and erythema gyratum repens (characterized by red, ring-like patches).

How Can Cancer Treatments Affect Skin?

Cancer treatments, including chemotherapy, radiation therapy, and immunotherapy, can have significant effects on the skin. Chemotherapy can cause side effects such as dry skin, rashes, and increased sensitivity to the sun. Radiation therapy can lead to radiation dermatitis, characterized by redness, peeling, and blistering of the skin. Immunotherapy may cause immune-related skin reactions, including rashes and vitiligo.

When to See a Dermatologist?

It is crucial to see a dermatologist if you notice any persistent changes in your skin, such as new growths, sores that don’t heal, or changes in existing moles. Early detection is vital for successful treatment, especially in the case of melanoma, which can be life-threatening if not treated promptly. Regular skin checks and monitoring for the ABCDE signs can help in early detection and management of skin cancer.

Preventive Measures

To reduce the risk of skin cancer, it is essential to take preventive measures, such as using a broad-spectrum sunscreen with an SPF of 30 or higher, wearing protective clothing, and avoiding tanning beds. Regular skin self-exams and annual dermatologist visits can aid in early detection and prevention of potential skin cancer.



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Issue Release: 2024

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