Rectal cancer - Cancer Science

What is Rectal Cancer?

Rectal cancer is a type of cancer that begins in the rectum, the last several inches of the large intestine closest to the anus. It is a subset of colorectal cancers, which also include cancers of the colon.

Causes and Risk Factors

The exact cause of rectal cancer is not fully understood, but several risk factors have been identified. These include age, typically over 50; a family history of colorectal cancer; inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis; and certain genetic syndromes like Lynch syndrome and Familial Adenomatous Polyposis (FAP). Lifestyle factors such as diet high in red or processed meats, smoking, and heavy alcohol use also play a significant role.

Symptoms

Symptoms of rectal cancer can include a change in bowel habits, such as diarrhea, constipation, or narrowing of the stool that lasts for more than a few days. Other symptoms may include rectal bleeding, blood in the stool, abdominal discomfort, a feeling that the bowel doesn't empty completely, and unexplained weight loss. It's important to note that these symptoms can also be indicative of other conditions, so they should be evaluated by a healthcare provider.

Diagnosis

Diagnosis typically involves a combination of diagnostic tests. A colonoscopy is often the primary method, allowing for a visual inspection and biopsy of any suspicious areas. Additional imaging tests such as CT scans, MRI, and PET scans may be used to determine the extent of the disease. Blood tests, including carcinoembryonic antigen (CEA) levels, can also be useful markers.

Treatment Options

Treatment for rectal cancer depends on the stage of the cancer. Early-stage cancers may be treated with surgery alone, often involving a procedure called a low anterior resection (LAR) or abdominoperineal resection (APR). More advanced cancers may require a combination of treatments, including radiation therapy, chemotherapy, and targeted therapies. In some cases, preoperative (neoadjuvant) therapy is used to shrink the tumor before surgery.

Prognosis

The prognosis for rectal cancer varies based on several factors, including the stage at diagnosis, the patient’s overall health, and the response to treatment. Early-stage rectal cancer has a relatively high survival rate, while more advanced stages have a lower prognosis. Ongoing follow-up care is crucial for monitoring recurrence and managing any long-term side effects of treatment.

Prevention

While not all cases of rectal cancer can be prevented, certain lifestyle changes can reduce the risk. These include maintaining a healthy diet rich in fruits, vegetables, and whole grains while limiting red and processed meats. Regular exercise, avoiding smoking, and limiting alcohol consumption are also recommended. Routine screening, especially for those at higher risk, can help detect precancerous changes or early-stage cancers when they are most treatable.

Conclusion

Rectal cancer is a significant health concern but advances in screening, diagnosis, and treatment have improved the outcomes for many patients. Awareness of the risk factors and symptoms, combined with regular screenings, can lead to early detection and more effective treatment. If you have any concerns or symptoms, it is crucial to consult with a healthcare provider for proper evaluation and management.



Relevant Publications

Partnered Content Networks

Relevant Topics