Not all skin rashes are indicative of cancer, but some can be. A persistent or unusual rash that does not respond to typical treatments might warrant further investigation. Certain types of rashes, such as those associated with paraneoplastic syndromes, can be indicative of an underlying malignancy. If you notice a rash that is accompanied by other symptoms like unexplained weight loss, fatigue, or fever, it is important to consult a healthcare provider.