Yes, there are several alternatives to opioids for managing cancer-related pain. These include non-opioid analgesics like acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), as well as adjuvant therapies like antidepressants and anticonvulsants that can help with certain types of pain. Non-pharmacological approaches, such as physical therapy, acupuncture, and cognitive-behavioral therapy, can also be effective.