Are There Any Approved Drugs Targeting Checkpoint Kinases?
Yes, there are several drugs in development and some already approved that target checkpoint kinases. For instance, Prexasertib is a CHK1 inhibitor that has shown promise in clinical trials, especially for cancers with high levels of replication stress. Another example is Adavosertib, a WEE1 kinase inhibitor, which indirectly affects checkpoint kinase activity and is being investigated for its efficacy in various cancers.
