What Challenges Exist in Targeting Checkpoint Kinases?
While targeting checkpoint kinases presents a promising therapeutic strategy, several challenges exist. One major challenge is the potential for toxicity, as normal cells also rely on checkpoint kinases for DNA damage repair. Another issue is the development of resistance, where cancer cells adapt to the inhibition of checkpoint kinases and continue to proliferate. Ongoing research is focused on overcoming these challenges by developing more selective inhibitors and combination therapies.
