Are There Any Challenges in Implementing Senolytic Therapies?
While promising, senolytic therapies face several challenges: - Specificity and Targeting: Ensuring that senolytic agents selectively target senescent cells without harming normal cells is crucial. Achieving this specificity is a significant challenge. - Side Effects: The potential side effects of senolytic therapies need thorough investigation. Eliminating senescent cells could have unintended consequences on tissue homeostasis and function. - Tumor Heterogeneity: Cancers are heterogeneous, meaning they consist of various cell types with different characteristics. This heterogeneity complicates the development of universally effective senolytic therapies.
