Several compounds have shown senolytic activity in preclinical studies, including: - Dasatinib: Originally developed as a cancer drug, dasatinib has shown senolytic activity, particularly in combination with other agents. - Quercetin: A plant flavonoid with senolytic properties, often used in combination with dasatinib. - Navitoclax: An inhibitor of the BCL-2 family of proteins, which regulate cell death, navitoclax has shown promise as a senolytic agent. - Fisetin: Another plant-derived compound, fisetin has demonstrated senolytic activity in various models.
