Are there any challenges in targeting MDSCs for cancer therapy?
One of the main challenges in targeting MDSCs for cancer therapy is their heterogeneity and plasticity. MDSCs can rapidly adapt to the tumor microenvironment, making it difficult to develop universal targeting strategies. Additionally, some therapeutic approaches targeting MDSCs may have off-target effects, leading to unintended immunosuppression or toxicity. Therefore, a deeper understanding of MDSC biology and the development of more specific and effective targeting strategies are crucial for overcoming these challenges.
