What are the key markers and signaling pathways involved in MDSC function?
Key markers for identifying MDSCs include surface proteins such as CD11b, CD33, CD14, and CD15. The signaling pathways involved in MDSC function are diverse and include the STAT3, NF-κB, and PI3K/Akt pathways. These pathways are crucial for the differentiation, expansion, and immunosuppressive activities of MDSCs. For example, the STAT3 pathway is often activated by tumor-derived factors and plays a pivotal role in promoting the accumulation and function of MDSCs in the tumor microenvironment.
