Are There Any Other Implications of IDH1 Mutations in Cancer?
Beyond therapeutic implications, IDH1 mutations also have a significant impact on cancer metabolism and epigenetics. The accumulation of 2-HG can inhibit enzymes involved in DNA and histone demethylation, leading to widespread changes in gene expression. This epigenetic reprogramming can contribute to the initiation and progression of cancer, highlighting the complex role of IDH1 in oncogenesis.
