Are there any resistance issues with Temozolomide?
Resistance to temozolomide can occur, often through the increased expression of DNA repair enzymes like O6-methylguanine-DNA methyltransferase (MGMT). This enzyme can repair the DNA damage caused by temozolomide, rendering the drug less effective. Testing for MGMT promoter methylation status can help predict the likelihood of response to temozolomide, and guide treatment decisions.
