her2 amplification

Are There Any Resistance Mechanisms to HER2-Targeted Therapies?

Despite the effectiveness of HER2-targeted therapies, resistance can develop in some patients. Mechanisms of resistance include:
Secondary mutations in the HER2 gene that alter the binding site of the targeted therapy.
Activation of alternative signaling pathways that can bypass HER2 inhibition.
Loss of HER2 amplification during treatment, leading to reduced dependency on the HER2 signaling.
Overcoming resistance to HER2-targeted therapies is an active area of research, with ongoing studies exploring combination therapies and novel agents.

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