Which Cancers are Associated with HER2 Amplification?
HER2 amplification is most commonly associated with breast cancer, where it is found in approximately 15-20% of cases. It is also observed in other types of cancers, including gastric cancer (10-30%), ovarian cancer, lung cancer, and bladder cancer. The presence of HER2 amplification is often correlated with a more aggressive disease and poorer prognosis.