Are There Any Therapeutic Approaches Targeting Glutamine Metabolism?
Several therapeutic strategies are being explored to target glutamine metabolism in cancer. These include:
Glutaminase inhibitors: These block the conversion of glutamine to glutamate, disrupting the metabolic pathways that cancer cells rely on. Amino acid transport inhibitors: These inhibit the transport of glutamine into cancer cells, thereby starving them of this essential nutrient. Dietary interventions: Some research suggests that a low-glutamine diet may help in reducing tumor growth, although this approach is still under investigation.
