What Are the Challenges in Targeting Glutamine Metabolism?
While targeting glutamine metabolism holds promise, several challenges exist:
Specificity: Ensuring that therapies selectively target cancer cells without affecting normal cells is crucial. Resistance: Cancer cells may develop resistance to glutamine-targeting therapies by activating alternative metabolic pathways. Tumor heterogeneity: Different types of cancer cells within a tumor may have varying dependencies on glutamine, complicating treatment strategies.
