Are There Genetic Variants of CYP3A4 That Impact Cancer?
CYP3A4 genetic polymorphisms can result in altered enzyme activity. For example, the CYP3A4*22 allele is associated with reduced enzyme activity. These genetic variants can affect how patients metabolize chemotherapeutic agents, influencing both treatment outcomes and the risk of adverse effects. Genetic testing for CYP3A4 variants may offer valuable insights for personalized cancer therapy.
