What Role Does CYP3A4 Play in Metabolizing Cancer Drugs?
CYP3A4 metabolizes numerous chemotherapeutic agents such as paclitaxel, docetaxel, and tamoxifen. The activity of CYP3A4 can determine the concentration of the active drug in the bloodstream, impacting its therapeutic effect and toxicity. Inhibitors or inducers of CYP3A4 can significantly alter the pharmacokinetics of these drugs, necessitating careful monitoring and dose adjustments.
