Are There Risks Associated with Targeting Immortality Mechanisms?
While targeting immortality mechanisms in cancer cells holds therapeutic potential, there are risks and challenges:
Off-Target Effects: Therapies that inhibit telomerase or other pathways may also affect normal stem cells, leading to side effects. Resistance: Cancer cells can develop resistance to targeted therapies, necessitating the combination of multiple treatment strategies. Tumor Heterogeneity: Different cells within the same tumor may rely on distinct mechanisms for immortality, complicating treatment.
