Are There Specific DNA Polymerase Mutations Associated with Certain Cancers?
Yes, specific mutations in DNA polymerases are associated with particular types of cancer. For instance, Pol ε mutations are frequently found in ultramutated tumors such as endometrial and colorectal cancers. These mutations often occur in the exonuclease domain, impairing the enzyme's proofreading capability. Similarly, Pol δ mutations have been identified in various cancers, including colorectal and ovarian cancers. The presence of these mutations can serve as biomarkers for cancer diagnosis and prognosis.
