Are There Specific Kinetochore Proteins Implicated in Cancer?
Several kinetochore proteins have been implicated in cancer. Notable examples include NDC80, CENP-A, CENP-E, and BubR1. Overexpression of NDC80, for instance, has been linked to poor prognosis in various cancers, such as breast and colorectal cancers. Similarly, alterations in CENP-A expression have been associated with chromosomal instability and tumorigenesis.