What Are the Challenges in Targeting the Kinetochore?
While targeting the kinetochore holds promise, there are several challenges. One major issue is the potential for toxicity in normal cells, which also rely on kinetochore function for proper cell division. Achieving specificity in targeting cancer cells without affecting normal cells remains a significant hurdle. Additionally, cancer cells often develop resistance to therapies, and this could extend to kinetochore-targeting agents. Understanding the mechanisms of resistance and developing combination therapies may be necessary to overcome these challenges.
