Are There Therapeutic Approaches Targeting E-Cadherin?
Given the crucial role of E-Cadherin in maintaining cellular adhesion and preventing metastasis, restoring its function or enhancing its expression is a potential therapeutic strategy. Some of the approaches being investigated include:
Gene Therapy: Introducing functional copies of the CDH1 gene into cancer cells to restore E-Cadherin expression. Epigenetic Modifiers: Using drugs that reverse promoter methylation or inhibit transcriptional repressors to upregulate E-Cadherin expression. Protease Inhibitors: Developing inhibitors that block the degradation of E-Cadherin by proteolytic enzymes.
