How Does E-Cadherin Loss Contribute to Cancer Progression?
The loss of E-Cadherin function can trigger a process known as epithelial-to-mesenchymal transition (EMT). During EMT, epithelial cells lose their cell-cell adhesion properties and gain mesenchymal traits, including increased migratory capacity and invasiveness. This transition is a critical step in the dissemination of cancer cells from the primary tumor to distant sites in the body, facilitating metastasis.
