Kinesins are particularly significant in cancer due to their role in mitosis. Kinesin family member 11 (KIF11), for example, is essential for mitotic spindle formation. Inhibitors targeting KIF11 have shown promise in preclinical studies as potential anti-cancer agents. Additionally, kinesin family member 20A (KIF20A) is often overexpressed in cancers such as pancreatic and liver cancer, making it a potential biomarker and therapeutic target.
