Can Autophagy Inhibition Be a Therapeutic Strategy?
Given its role in cancer survival, targeting the autophagy-lysosome pathway has become an attractive therapeutic strategy. Inhibitors of autophagy, such as chloroquine and its derivatives, are being investigated in combination with chemotherapy to enhance cancer cell death. These drugs hinder the fusion of autophagosomes with lysosomes, thereby blocking autophagic flux and sensitizing cancer cells to treatment. Clinical trials are ongoing to evaluate the efficacy of autophagy inhibitors in various cancer types.
