Can CpG Island Methylation be Targeted for Cancer Therapy?
Yes, targeting the methylation of CpG islands holds promise for cancer therapy. Demethylating agents, such as azacitidine and decitabine, are used to reverse abnormal methylation patterns, thus reactivating silenced tumor suppressor genes. Epigenetic therapies that modify CpG island methylation are an active area of research and have shown efficacy in various types of cancer.
