Can DNA Methylation Be Targeted for Cancer Therapy?
Yes, DNA methylation can be targeted for cancer therapy. Drugs known as DNA methyltransferase inhibitors (DNMT inhibitors) are designed to reverse abnormal methylation patterns. Examples include azacitidine and decitabine, which are used to treat certain types of leukemia and myelodysplastic syndromes. These drugs can reactivate silenced tumor suppressor genes, thereby inhibiting cancer growth.
