chromosome segregation

Can Faulty Chromosome Segregation be Targeted in Cancer Therapy?

Yes, targeting faulty chromosome segregation presents a promising avenue for cancer therapy. Strategies include:
Inhibiting proteins involved in spindle assembly and function, such as Aurora kinases and Kinesin spindle protein (KSP).
Targeting the spindle assembly checkpoint to selectively kill aneuploid cancer cells.
Exploiting vulnerabilities in cancer cells with high levels of genomic instability by using PARP inhibitors.

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