What Are the Mechanisms Behind Faulty Chromosome Segregation?
Several mechanisms can lead to faulty chromosome segregation in cancer cells:
Centrosome abnormalities: Cancer cells often exhibit centrosome amplification, resulting in multipolar spindles that missegregate chromosomes. Cohesion defects: Errors in the proteins that hold sister chromatids together can cause premature separation and unequal chromosome distribution. Kinetochore-microtubule attachments: Faulty attachments can lead to improper chromosome alignment and segregation. Spindle assembly checkpoint (SAC) defects: Malfunctioning SAC allows cells to proceed through mitosis with misaligned chromosomes, leading to aneuploidy.
