Several factors contribute to the development of secondary malignancies:
Chemotherapy: Certain chemotherapeutic agents, such as alkylating agents and topoisomerase inhibitors, have been linked to an increased risk of secondary cancers like leukemia. Radiation Therapy: Exposure to radiation, especially in younger patients, can increase the risk of developing secondary cancers in the irradiated field. Genetic Factors: Some individuals have genetic mutations that predispose them to multiple cancer types. For example, mutations in the BRCA1 and BRCA2 genes increase the risk of breast and ovarian cancers, among others. Lifestyle Factors: Smoking, alcohol consumption, and other lifestyle choices can also contribute to the development of secondary malignancies.
