Can Genetic Instability Be Targeted for Cancer Therapy?
Yes, genetic instability can be targeted for cancer therapy. For example:
- PARP Inhibitors: Target cancers with deficiencies in homologous recombination repair, such as BRCA-mutated cancers. - Checkpoint Inhibitors: Exploit the high mutation burden in some cancers to enhance immune response. - Synthetic Lethality: Exploits vulnerabilities created by specific genetic alterations to selectively kill cancer cells.
