What are Some Common Genetic Alterations in Cancer?
Common genetic alterations in cancer include:
- Point Mutations: Single nucleotide changes that can activate oncogenes or inactivate tumor suppressor genes. - Chromosomal Translocations: Rearrangements that create fusion genes with oncogenic properties. - Gene Amplifications: Increased copies of oncogenes, leading to overexpression. - Loss of Heterozygosity: Loss of one allele of a gene where the remaining allele is insufficient for normal function.
