While it is not possible to prevent the genetic mutations that cause HNPCC, proactive measures can be taken to manage and reduce cancer risk. Regular screening and surveillance, prophylactic surgeries (such as colectomy or hysterectomy), and lifestyle modifications (like a healthy diet and avoiding smoking) can help mitigate the risk. Genetic counseling is also important for individuals with HNPCC and their families to understand their risk and make informed decisions about their health.