While hyperplastic polyps themselves are typically benign, certain subtypes and specific locations may warrant closer attention. For instance, large hyperplastic polyps located in the right side of the colon (also known as proximal colon) may be associated with an increased risk of [colorectal cancer](https://). This is particularly true in the context of [serrated polyposis syndrome](https://), a condition characterized by the presence of multiple serrated polyps.