Can Nonsense Mutations be Targeted Therapeutically?
Yes, there are therapeutic strategies aimed at addressing the consequences of nonsense mutations. One such approach involves the use of nonsense suppression therapies, which employ drugs to read through premature stop codons, allowing for the production of full-length, functional proteins. Another method includes gene editing technologies like CRISPR-Cas9, which can potentially correct the mutation at the DNA level. Additionally, immunotherapy and targeted therapy can be tailored to exploit the specific vulnerabilities created by nonsense mutations in cancer cells.
