Given its role in apoptosis, PUMA is an attractive target for cancer therapy. Strategies to upregulate PUMA expression or mimic its activity are being explored to enhance the efficacy of existing treatments. For instance, drugs that activate the p53 pathway or inhibit anti-apoptotic Bcl-2 proteins can indirectly increase PUMA activity. Additionally, gene therapy approaches aim to deliver functional PUMA directly to cancer cells.
