PUMA, which stands for p53 upregulated modulator of apoptosis, is a protein that plays a crucial role in the process of apoptosis (programmed cell death). The PUMA protein is a member of the Bcl-2 family and is encoded by the BBC3 gene. Its primary function is to promote cell death in response to stress signals, particularly those triggered by the activation of the tumor suppressor protein, p53.
